SCOPOLAMINE

DescriptionSCOPOLAMINE has a special site of action at the parasympathetic ganglia in the walls of the viscera. Because of this it exerts a specific antispasmodic action on the smooth muscle of the gastro-intestinal, biliary and urinary tracts, this action being produced long before the side effects characteristic of atropine-like substances occur. Hence, no side effects on the central nervous system or salivary glands are observed when SCOPOLAMINE is administered in therapeutic doses.

Composition: 1 ampoule of 1 ml contains 20.0 mg Hyoscine-N-butylbromide. Detailed Indications: Gastric and duodenal ulcers, gastro-intestinal spasm and hypermotility, pylorospasm in infants, post-operative vomiting, spastic constipation, biliary dyskinesia and spasm of the urinary tract, delayed relaxation of the lower uterine segment, dysmenorrhoea. Contraindications: There are no known contraindications for the oral administration of SCOPOLAMINE, but it should not be administered parenterally in the following disorders: Glaucoma, hypertrophy of the prostate with a tendency towards retention of urine, mechanical stenoses in the region of the gastro-intestinal tract, tachycardia, megacolon.

Side Effects: No adverse effects characteristic of atropine are observed on the salivary glands or sweat secretion when SCOPOLAMINE is administered in the usual dose. A slight increase in pulse rate may occur when it is administered intravenously. Parenteral administration, especially of large doses, may occasionally cause a transient disturbance of accommodation, which recedes spontaneously. For these reasons, following parenteral administration, even when given as instructed, SCOPOLAMINE can affect vision and consequently reactions while driving or operating machinery.

Drug Interaction: On parenteral administration of SCOPOLAMINF tricyclic antidepressants, quinidine and amantadine can potentiate the anticholinergic effect of SCOPOLAMINE. Dosage & Administration: Unless otherwise prescribed by the physician: Parenteral: In acute attacks of colic 1 ampoule of SCOPOLAMINE (20 mg) may be administered subcutaneously, intramuscularly or by intravenous injection several times daily. Infants and young children: In severe cases, 1/4 of an ampoule 3 times daily.

Precautions: Available but limited pre-clinical data has shown no hazard, but safety during pregnancy has not yet been established. The usual precautions regarding the use of drugs at this time, especially during the first trimester, should be observed. Safety during lactation has not yet been established.

Packing: 5 Ampoules.

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