Generic Name: Pefloxacin
Dosage Form: Film-Coated Tablets
Packaging: 10 Tablets
*Packaging design and product name may be different in your country.
Each film-coated tablet of Peflacine 400 mg contains :
Indications for pefloxacin are based on its antibacterial activity, the pharmacokinetic properties and the results obtained from controlled clinical trials.
They are limited in adults to the treatment of serious infections caused by Gram negative and Staphylococci susceptible strains, particularly in the following locations:
Streptococci and Pneumococci are inconstantly susceptible to pefloxacin, this product should not be used as first line therapy when such a strain is suspected.
The combination of another antibiotic may be justified when the emergence of resistant Pseudomonas aeruginosa and Staphyloccocus aureus is observed. Microbiological monitoring of such resistance should be considered especially when treatment failure is suspected.
800 mg/day (either 2 tablets or 2 ampoules containing 400 mg of pefloxacin)
In order to reach effective blood concentration more rapidly, an initial loading dose of 800mg may be given.
Patients with severe hepatic insufficiency or reduced hepatic blood flow, the daily dosage must be adjusted by increasing the intervals between the doses.
For the injectable forms, injections should be given by intravenous infusion at the rate of 8 mg/kg in one hour:
Peflacine tablets must be taken in the morning and in the evening with meals in order to minimize gastro-intestinal disorders.
Peflacine injections must be administered by slow intravenous infusion during one hour, after the dilution of the solution contained in the ampoule into 125 or 250 ml of 5% glucose solution. Two infusions of 400 mg/day, one in the morning one in the evening.
Saline solution or other solution containing chloride ions must be avoided because of the risk of precipitation.
*The information provided above is general in nature and for informational purposes only. It is NOT a substitute for the advice of your doctor. You must always consult your healthcare professional before starting any medication/supplementation program.