OBARSIX is a loop diuretic, it inhibits the active reabsorption of sodium and chloride in the proximal and distal tubules and the loop of Hanley.

A consequence of the elevated sodium level in the distal region of the tubule is the increased excretion of potassium.

OBARSIX has very pronounced diuretic of action.

Each tablet of OBARSIX contains: Furosemide 40 mg.

Edema: associated with congestive heart failure, cirrhosis of the liver and renal disease, including the nephrotic syndrome.

Hypertension: oral OBARSIX may be used alone or with combination with other antihypertensive agents.

Pregnancy& breast-feeding

Pregnancy: there are no adequate and well-controlled studies in pregnant women. Furosemide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus (Pregnancy category: C).

Breast-feeding: because it appears in breast milk, caution should be exercised.

Edema:

Adults:

The usual initial dose is 20 to 80 mg given as a single dose. Ordinarily a prompt diuresis ensures.

The same dose can be administrated 6 to 8 hours later or the dose may be increased.

The dose may be carefully titrated up to 600 mg/day in patients with clinically severe edematous states.

 Edema may be most efficiently and safety mobilized by giving OBARSIX on 2 to 4 consecutive days each week.

Pediatric patients:

The usual initial dose of oral OBARSIX is 2 mg/kg body weight, given as a single dose.

If the diuretic response is not satisfactory after the initial dose, dosage may be increased by 1 or 2 mg/kg no sooner than 6 to 8 hours after the previous dose.

Dosage greater than 6 mg/kg body weight are not recommended.

Hypertension in Adults:

The usual initial dose for hypertension is 80 mg, usually divided into 40 mg twice a day.

Dosage should be adjusted according to response.

To prevent excessive drop in blood pressure, the dosage of other anti-hypertensive agents should be reduced by at least 50 % when Furosemide is added to the regimen.