Generic Name: Cefepime HCl monohydrate
Dosage Form: Vial
Packaging: 1 vial with 1 WFI ampoule
*Packaging design and product name may be different in your country.
Cefepime dihydrochloride monohydrate is a semi-synthetic, broad spectrum, cephalosporin antibiotic for parenteral administration.
Each vial contains :
Acepime (Cefepime dihydrochloride monohydrate) is indicated in the treatment of the following infections caused by susceptible strains of the designated microorganisms:
1- 2 g IV, every 12h , for 10 days.
2 g IV , every 8h , for 7 days.
0.5- 1g , IV/ IM, every 12h , for 7- 10 days.
2 g IV , every 12h , for 10 days.
2 g IV, every 12h, for 10 days.
2 g IV, every 12h , for 7- 10 days.
The recommended initial dose of Acepime should be the same as in patients with normal renal function. The recommended maintenance doses of Acepime in patients with renal insufficiency are presented in the following table:
Recommended Maintenance Schedule in Adult Patients with Renal Impairment Relative to Normal Recommended Dosing Schedule:
|Creatinine Clearance (ml/min)||Recommended Maintence Schedule|
|>60 normal recommended dosing schedule||500mg q 12h / 1g q 12h / 2g q 12h / 2g q 8h|
|30- 60||500mg q 24h / 1g q 24h / 2g q 24h / 2g q 12h|
|11- 29||500mg q 24h / 500mg q 24h / 1g q 24h / 2g q 24h|
|<11||250mg q 24h / 250mg q 24h / 500mg q 24h / 1g q 24h|
In patients undergoing hemodialysis, approximately 68% of the total amount of Cefepime present in the body at the start of dialysis will be removed during a 3-hour dialysis period. A repeat dose, equivalent to the initial dose, should be given at the completion of each dialysis session.
In patients undergoing continuous ambulatory peritoneal dialysis, Acepime may be administered at normally recommended doses at a dosage interval of every 48 hours.
For IV administration, the vials 500mg, 1g, or 2g should be constituted by adding the appropriate volumes, as shown below, of one of the following IV fluids: 0.9% Sodium Chloride Injection, 5% and 10% Dextrose Injection , sodium lactate injection, 5% Dextrose and 0.9% sodium chloride injection, Lactated Ringers and 5% Dextrose Injection. These solutions may be stored up to 24 hours at controlled room temperature 20˚- 30˚ C or 7 days in a refrigerator 2˚- 8˚ C. The resulting solution should be administered over approximately 30 minutes
For IM administration, Acepime (Cefepime dihydrochloride monohydrate) should be reconstituted, as shown below, with one of the following diluents: Sterile Water for Injection, 0.9% sodium chloride, 5% dextrose injection, 0.5% or 1.0% lidocaine hydrochloride, or sterile bacteriostatic water for injection with parabens or benzyl alcohol. The resulting solutions are stable for 24 hours at controlled room temperature 20˚-25˚ C or for 7 days in a refrigerator 2˚- 8˚ C.
Preparation of Solutions of Acepime:
|Single Dose Vials for Intravenous / Intramuscular Administration||Amount of Diluents to be Added (ml)||Approximate Available Volume (ml)||Approximate Cefepime Concentration (mg/ml)|
Note: Parenteral drugs should be inspected visually for particulate matter before administration.
*The information provided above is general in nature and for informational purposes only. It is NOT a substitute for the advice of your doctor. You must always consult your healthcare professional before starting any medication/supplementation program.