Generic Name: Cefotaxime sodium
Dosage Form: Vial
Packaging: 1 vial with 1 WFI ampoule
*Packaging design and product name may be different in your country.
Cefolin (Cefotaxime sodium) is a semisynthetic broad spectrum 3rd generation cephalosporin antibiotic for parenteral administration.
Each vial contains:
Cefolin is indicated for the treatment of the following infections due to susceptible microorganisims: lower respiratory tract infections including pneumonia, genitourinary infections including uncomplicated gonorrhea (cervical , urethral and rectal), gynecologic infections including pelvic inflammatory disease , endometritis and pelvic cellulitis , but cefotaxime has no activity against chlamydia trachomatis, therefore if C. trachomatis is one of the suspected pathogens, appropriate antichlamydial coverage should be added.ِِِِAlso cefolin is indicated for the treatment of bacteremia and septicemia, skin and skin structure infections, intra – abdominal infections including peritonitis , bone and joint infections , central nervous system infections e.g., meningitis and ventriculitis .
Note cefotaxime sodium and aminoglycosides have been shown to be synergistic against some strains of pseudomonas aeruginosa.
Cefolin is administered by intramuscular or intravenous injection and the following table shows the guidelines for the recommended dosage of Cefolin:
Give the first dose of 1 gram IV as soon as the umbilical cord is clamped , the second and third doses should be given as 1 gr. IV or IM at 6 and 12 hours after the first dose.
0-1 week of age, 50 mg / kg per dose every 12 hours IV.
1-4 weeks of age 50 mg / kg per dose every 8 hours IV.
If creatinine clearance is less than 20 ml / min / 1.73 m², the dose of cefolin should be halved. Cefolin is reconstituted as follows:
|Route Of Administration|
|Strength of Cefolin vial||I.M route Lidocaine 1 % Solution (ml)||I.V route sterile water for injection ( ml )|
|500 mg||4 ml||2 ml|
|1 gram||4 ml||4 ml|
|2 grams||——–||10 ml|
The color of the solution range from pale yellow to light amber , for I.V use the vials should be reconstitute with sterile water for injection , and a solution containing 1 or 2 gr. in 10 ml of sterile water for injection should be injected over a period of 3-5 min.
For I.M. use the vials should be reconstitute with sterile water for injection , the 500 mg or 1 g for I.M. only could be reconstitute with 4 ml of Lidocaine 1 % solution .
*The information provided above is general in nature and for informational purposes only. It is NOT a substitute for the advice of your doctor. You must always consult your healthcare professional before starting any medication/supplementation program.